Fabrication, Characterization and In Vitro Drug Release Behavior of Electrospun Eudragit/Eugenol Nanofibrous Scaffold 


Vol. 25,  No. 8, pp. 2817-2833, Aug.  2024
10.1007/s12221-024-00622-4


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  Abstract

The current work focuses on preparing the eudragit-based nanofiber loaded with eugenol, a potential anti-inflammatory drug. The avenue of the study is to unravel the applicability of drug-loaded polymer nanofiber for periodontal intra-pocket drug delivery. Incorporation of about 1-3% of eugenol in to the eudragit matrix certainly enhanced its properties. As revealed by FE-SEM, nanofibrous mat had well-branched and porous structure with a diameter range of 261 nm-412 nm. The presence of functional groups and interaction of the drug with the polymer through hydrogen bonding was confirmed by the shift of the absorption band to lower wavenumbers in the FTIR spectrum. Contact angle measurement and swelling behavior assessment showed that mat with 3% drug had better surface wettability (359.17 ± 9.21) and lower hydrophobicity (119.80º) in comparison with eudragit matrix. Non-toxic behavior of the developed nanofiber is established by both in vitro cell viability (greater than 80%) and in vivo Drosophila melanogaster model (greater than 78% survival rate). Polymer/drug composite also revealed satisfactory anti-inflammatory activity of about 97% at 12.5 µg/ml concentrations. Further, the cumulative drug release of eugenol from nanofiber mat was found to be 83.60 ± 2.01% for 3% eugenol-loaded sample in the in vitro model with R2 (0.9681) fitting to Korsmeyer-Peppas model indicating diffusion mechanism for prolonged release in dose-dependent manner (n=0.25, k=10. 81 min-1). These findings indicated that the fabricated eudragit/eugenol composite mat is a promising system for intra-pocket drug delivery in periodontitis therapy.

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  Cite this article

[IEEE Style]

S. Kakunje, N. Badiadka, S. B. Kunhanna, S. Mahammad, Suchitra, R. P. Devasya, D. B. Sesappa, S. V. Raghu, "Fabrication, Characterization and In Vitro Drug Release Behavior of Electrospun Eudragit/Eugenol Nanofibrous Scaffold," Fibers and Polymers, vol. 25, no. 8, pp. 2817-2833, 2024. DOI: 10.1007/s12221-024-00622-4.

[ACM Style]

Shreevani Kakunje, Narayana Badiadka, Sarojini Balladka Kunhanna, Sajida Mahammad, Suchitra, Rekha Punchappady Devasya, Dayananda Bikrodi Sesappa, and Shamprasad Varija Raghu. 2024. Fabrication, Characterization and In Vitro Drug Release Behavior of Electrospun Eudragit/Eugenol Nanofibrous Scaffold. Fibers and Polymers, 25, 8, (2024), 2817-2833. DOI: 10.1007/s12221-024-00622-4.

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pISSN : 1229 - 9197
eISSN : 1875 - 0052

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