Tannic Acid/Gelatin/Sodium Alginate Multifunctional Composite Hydrogels with Biocompatible and Antibacterial Properties 


Vol. 26,  No. 12, pp. 5321-5332, Dec.  2025
10.1007/s12221-025-01191-w


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  Abstract

Gelatin has been widely employed as a biomaterial for wound dressing fabrication owing to its excellent biocompatibility. However, its applications are limited by structural instability and lack of multifunctionality. To address these limitations, we developed a novel tannic acid/gelatin/sodium alginate (TA/Gel/SA) composite hydrogel through hydrogen bonding and Michael addition reactions under alkaline conditions. Comprehensive characterization revealed that the incorporation of tannic acid at a concentration of 0.6 wt% significantly enhanced the hydrogel's cross-linking density and mechanical strength. Furthermore, the modified hydrogel exhibited remarkable antibacterial properties with an inhibition zone diameter of 42.5 mm and antioxidant properties with a radical scavenging rate of 75%, along with substantially improved blood coagulation capability. The material demonstrated an acceptable hemolysis rate, meeting essential requirements for wound care applications. With its superior biocompatibility and multifunctional performance, this TA/Gel/SA hydrogel shows promising potential for biomedical applications, particularly in advanced wound management systems.

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  Cite this article

[IEEE Style]

Q. Kong, X. Hu, Y. Wu, Z. Li, "Tannic Acid/Gelatin/Sodium Alginate Multifunctional Composite Hydrogels with Biocompatible and Antibacterial Properties," Fibers and Polymers, vol. 26, no. 12, pp. 5321-5332, 2025. DOI: 10.1007/s12221-025-01191-w.

[ACM Style]

Que Kong, Xinyi Hu, Yilin Wu, and Zhiguang Li. 2025. Tannic Acid/Gelatin/Sodium Alginate Multifunctional Composite Hydrogels with Biocompatible and Antibacterial Properties. Fibers and Polymers, 26, 12, (2025), 5321-5332. DOI: 10.1007/s12221-025-01191-w.

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pISSN : 1229 - 9197
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