Vancomycin Loaded Gelatin Microspheres Containing Wet Spun Poly(琯-caprolactone) Fibers and Films for Osteomyelitis Treatment 


Vol. 20,  No. 11, pp. 2236-2246, Nov.  2019
10.1007/s12221-019-9271-7


PDF
  Abstract

In this study, it was aimed to develop drug eluting biodegradable and biocompatible bone supportive fibers and films, which can locally be applicable on the infected bone defect area for osteomyelitis treatment. For this purpose, vancomycin (Vm) loaded gelatin (G) microspheres were prepared and dispersed into poly(琯-caprolactone) (PCL) solution and then the suspension was processed as films and fibers by solvent casting and wet spinning techniques, respectively. The mean particle size distribution and morphology of Vm loaded G microspheres were characterized by laser diffraction method and scanning electron microscopy, respectively. In vitro Vm release profiles and release kinetics from microsphere, fiber and film formulations were investigated. In vitro biodegradation properties of fiber and film formulations were examined in both hydrolytic and enzymatic media during 25 days period. The cytotoxicity of Vm eluting films and fibers were tested on L929 cells by MTT assay. Presence of PCL in film and fiber formulations retarded the release of Vm from microspheres and provided long term sustained release. Vm eluting films and fibers exhibited strong antibacterial properties against Staphylococcus aureus and Staphylococcus epidermidis.

  Statistics
Cumulative Counts from November, 2022
Multiple requests among the same browser session are counted as one view. If you mouse over a chart, the values of data points will be shown.


  Cite this article

[IEEE Style]

E. A. Aksoy, B. S. Yagci, G. Manap, I. Eroglu, S. Ozturk, M. Ekizoglu, K. Ulubayram, "Vancomycin Loaded Gelatin Microspheres Containing Wet Spun Poly(琯-caprolactone) Fibers and Films for Osteomyelitis Treatment," Fibers and Polymers, vol. 20, no. 11, pp. 2236-2246, 2019. DOI: 10.1007/s12221-019-9271-7.

[ACM Style]

Eda Ayse Aksoy, Betul Suyumbike Yagci, Gulseher Manap, Ipek Eroglu, Sukru Ozturk, Melike Ekizoglu, and Kezban Ulubayram. 2019. Vancomycin Loaded Gelatin Microspheres Containing Wet Spun Poly(琯-caprolactone) Fibers and Films for Osteomyelitis Treatment. Fibers and Polymers, 20, 11, (2019), 2236-2246. DOI: 10.1007/s12221-019-9271-7.

Search
(IN TITLE, AUTHOR, ABSTRACT,KEYWORDS)

Advanced Search ▼

POPULAR KEYWORDS
(TOP 10 KEYWORDS)

Recent Publications
(LAST 3 YEARS)

pISSN : 1229 - 9197
eISSN : 1875 - 0052

Impact Factor(2022): 2.5