A Novel and Inexpensive Method Based on Modified Ionic Gelation for pH-responsive Controlled Drug Release of Homogeneously Distributed Chitosan Nanoparticles with a High Encapsulation Efficiency 


Vol. 21,  No. 9, pp. 1917-1926, Sep.  2020
10.1007/s12221-020-1095-y


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  Abstract

Homogeneous chitosan nanoparticles utilizing EPR effect and pH-sensitive properties have an immense potential for loading and delivery of anticancer drugs. The aim of this study was preparing doxorubicin-loaded homogeneously distributed chitosan nanoparticles by using a simple and mild method, modified ionic gelation, with a very high encapsulation efficiency for controlled and pH-sensitive release. FESEM image revealed that the synthesized chitosan nanoparticles had a uniform spherical morphology with the size range 20-35 nm. The parameters of drug stirring duration, drug amount and nanoparticles formation time were changed to achieve maximum encapsulation efficiency as well as the effect of each parameter on the encapsulation efficiency was studied. The encapsulation efficiency toward doxorubicin under optimal conditions was 81.6

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  Cite this article

[IEEE Style]

S. Gooneh-Farahani, S. M. Naghib, M. R. Naimi-Jamal, "A Novel and Inexpensive Method Based on Modified Ionic Gelation for pH-responsive Controlled Drug Release of Homogeneously Distributed Chitosan Nanoparticles with a High Encapsulation Efficiency," Fibers and Polymers, vol. 21, no. 9, pp. 1917-1926, 2020. DOI: 10.1007/s12221-020-1095-y.

[ACM Style]

Sahar Gooneh-Farahani, Seyed Morteza Naghib, and M. Reza Naimi-Jamal. 2020. A Novel and Inexpensive Method Based on Modified Ionic Gelation for pH-responsive Controlled Drug Release of Homogeneously Distributed Chitosan Nanoparticles with a High Encapsulation Efficiency. Fibers and Polymers, 21, 9, (2020), 1917-1926. DOI: 10.1007/s12221-020-1095-y.