Biocompatibility of Polyimide Fibers with Human Gastric Cells In Vitro 


Vol. 22,  No. 9, pp. 2380-2387, Sep.  2021
10.1007/s12221-021-0199-3


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  Abstract

The selection of calibration materials and methods is of great significance, since accurate localization of intragastric lesions is crucial for diagnosis and post-treatment follow-up of gastric cancer. In this study, a novel suturing calibration method was adopted using polyimide (PI) fibers with outstanding comprehensive properties as the calibration material. The acid resistance in vitro of PI fibers and biocompatibility to MGC-803 human gastric cancer cells were investigated. In the simulated gastric acid erosion environment, the color of PI fibers remained to be bright yellow and the tensile strength maintained at 1.09 GPa without degradation of chemical structure. Moreover, PI fibers possessed high crystallinity, smooth surface as well as high-oriented fractured morphologies, and exhibited excellent structural and property resistance to simulated gastric acid, which was responsible for the biocompatibility. PI fibers showed no influence on the viability, morphology or lactate dehydrogenase level of gastric cells through direct and indirect extract contact. Therefore, PI fibers showed good stability in simulated gastric acid and were not cytotoxic to human gastric cells, suggesting their utility as markers of intragastric lesions.

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  Cite this article

[IEEE Style]

B. o. P. F. w. H. G. C. I. Vitro, "Biocompatibility of Polyimide Fibers with Human Gastric Cells In Vitro," Fibers and Polymers, vol. 22, no. 9, pp. 2380-2387, 2021. DOI: 10.1007/s12221-021-0199-3.

[ACM Style]

Biocompatibility of Polyimide Fibers with Human Gastric Cells In Vitro. 2021. Biocompatibility of Polyimide Fibers with Human Gastric Cells In Vitro. Fibers and Polymers, 22, 9, (2021), 2380-2387. DOI: 10.1007/s12221-021-0199-3.

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