Physicochemical Properties of TPP-Crosslinked Chitosan Nanoparticles as Potential Antibacterial Agents 


Vol. 22,  No. 11, pp. 2954-2964, Nov.  2021
10.1007/s12221-021-0397-z


  Abstract

Chitosan (CS) nanoparticles with antibacterial properties have been synthesized by the ionic gelation method using tripolyphosphate (TPP) as a crosslinking agent. Physicochemical properties of the resulting CS-TPP nanoparticles were examined by FTIR spectroscopy, X-ray diffraction, scanning electron microscopy, energy dispersive X-ray, transmission electron microscopy, and UV-Vis spectroscopy. The antibacterial efficacy of the nanoparticles against S. aureus and E. coli was evaluated by the disc diffusion (DD) method. It was found that the optimum conditions for fabricating the CS-TPP nanoparticles were: pH of 2.85, CS concentration of 1.5 mg/ml, TPP concentration of 0.5 mg/ml, CS:TPP feed ratio of 1:1, mixing speed of 300 rpm, and reaction temperature of 30

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  Cite this article

[IEEE Style]

F. Khoerunnisa, M. Nurhayati, F. Dara, R. Rizki, M. Nasir, H. A. Aziz, H. Hendrawan, N. E. Poh, C. Kaewsaneha, P. Opaprakasit, "Physicochemical Properties of TPP-Crosslinked Chitosan Nanoparticles as Potential Antibacterial Agents," Fibers and Polymers, vol. 22, no. 11, pp. 2954-2964, 2021. DOI: 10.1007/s12221-021-0397-z.

[ACM Style]

Fitri Khoerunnisa, Mita Nurhayati, Fitri Dara, Regita Rizki, Muhamad Nasir, Hafiz Aji Aziz, Hendrawan Hendrawan, Ng Eng Poh, Chariya Kaewsaneha, and Pakorn Opaprakasit. 2021. Physicochemical Properties of TPP-Crosslinked Chitosan Nanoparticles as Potential Antibacterial Agents. Fibers and Polymers, 22, 11, (2021), 2954-2964. DOI: 10.1007/s12221-021-0397-z.

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pISSN : 1229 - 9197
eISSN : 1875 - 0052

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