Antibacterial Chitosan-gelatin Hydrogel Beads Cross-linked by Riboflavin under Ultraviolet A Irradiation 


Vol. 23,  No. 2, pp. 315-320, Feb.  2022
10.1007/s12221-021-0401-7


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  Abstract

Antibacterial beads with good mechanical stability and antibacterial activity have been widely used in the biomedical field, and chitosan-gelatin (CS/GE) hydrogel beads were prepared by a cross-linking reaction between chitosan and gelatin triggered by photo-induced radicals generated from riboflavin. The results showed that SEM images revealed rough and hollow core structures on surfaces of the chemically crosslinked beads. Decreases of swelling ratio and amounts of amino/hydroxyl groups and increase of storage modulus values of the beads evidenced the crosslinking effect between CS and GE. The existence of both riboflavin and chitosan provided the crosslinked CS/GE beads with good antibacterial activity against E. coli. Riboflavin serves as a photosensitizer and an antimicrobial agent in the system, and increasing degree of crosslinking in the beads could lead to reduced antimicrobial function of the agent. In sum, the successful fabrication of these fascinating materials could provide new insights for development of functional hydrogel products.

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  Cite this article

[IEEE Style]

S. Fu, L. Zhou, P. Zeng, S. Fu, "Antibacterial Chitosan-gelatin Hydrogel Beads Cross-linked by Riboflavin under Ultraviolet A Irradiation," Fibers and Polymers, vol. 23, no. 2, pp. 315-320, 2022. DOI: 10.1007/s12221-021-0401-7.

[ACM Style]

Shaoju Fu, Linghui Zhou, Pei Zeng, and Sida Fu. 2022. Antibacterial Chitosan-gelatin Hydrogel Beads Cross-linked by Riboflavin under Ultraviolet A Irradiation. Fibers and Polymers, 23, 2, (2022), 315-320. DOI: 10.1007/s12221-021-0401-7.

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