Single-step Synthesis and Characterization of Zr-MOF onto Wool Fabric: Preparation of Antibacterial Wound Dressing with High Absorption Capacity 


Vol. 23,  No. 2, pp. 404-412, Feb.  2022
10.1007/s12221-021-0211-y


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  Abstract

Improvement of curative herbal extracts effectiveness through novel drug delivery systems is a field of study for the researches nowadays. Zirconium-based metal-organic frameworks (Zr-MOFs) are one of the most capable porous nanocarriers that need a biocompatible template to be used in biomedical applications. In this work, Zr-MOF was synthesized into the wool fabric through in-situ one-pot method with different molar ratios. The final fabrics were characterized thoroughly using various techniques and the effect of components on monodispersity and nucleation tendency of Zr-MOF onto the surface of wool were explained. The resultant fabric stablished absolute wash durability, increased air-permeability up to twice and reasonable hydrophilicity. Tensile strength and young modulus decreased 30 and 1244 % and strain increased 66 %. Salvia Officinalis (SO) and Calendula Officinalis (CO) extracts were loaded onto the modified fabrics with 1154 and 1842 % increased absorption capacity. The release profiles showed domination of diffusion mechanism. The wool-MOF-SO and CO displayed both 100 % antibacterial activity against Escherichia coli and 60.95 and 64.64 % against Staphylococcus aureus because of diverse antibacterial components. Calendula Officinalis proved biocompatibility with human skin however Salvia Officinalis exhibited high toxicity.

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  Cite this article

[IEEE Style]

R. Rezaee, M. Montazer, A. Mianehro, M. Mahmoudirad, "Single-step Synthesis and Characterization of Zr-MOF onto Wool Fabric: Preparation of Antibacterial Wound Dressing with High Absorption Capacity," Fibers and Polymers, vol. 23, no. 2, pp. 404-412, 2022. DOI: 10.1007/s12221-021-0211-y.

[ACM Style]

Reihane Rezaee, Majid Montazer, Ali Mianehro, and Mahnaz Mahmoudirad. 2022. Single-step Synthesis and Characterization of Zr-MOF onto Wool Fabric: Preparation of Antibacterial Wound Dressing with High Absorption Capacity. Fibers and Polymers, 23, 2, (2022), 404-412. DOI: 10.1007/s12221-021-0211-y.

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pISSN : 1229 - 9197
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