Poly(lactic acid) Nanofibrous Scaffolds Containing Aspirin-loaded Zeolitic Imidazolate Frameworks: Morphology, Drug Release, Hemocompatibility and Shape Memory Studies 


Vol. 23,  No. 8, pp. 2103-2113, Aug.  2022
10.1007/s12221-022-4163-7


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  Abstract

Using poly(lactic acid) (PLA) as biodegradable and biocompatible material is demanded for vascular scaffolds especially a susceptible substitute of permanent metal stents in treatment of coronary heart disease. In this work, PLA nanofibers containing aspirin (Asp) loaded into zeolitic imidazolate framework nanoparticles (ZIF-8@Asp NPs) were prepared for vascular tissue application. In this line, ZIF-8@Asp NPs were synthesized, and their characterization revealed their average NP size and the drug loading efficiency of approximately 180 nm and 76 %. Afterward, ZIF-8@Asp NPs were loaded into PLA nanofibers and the obtained results showed a uniform morphology with an average nanofibers diameter of around 544 nm, Young셲 modulus of 1.7 MPa, and the ultimate drug release of 19 % after six days. Besides degradation studies of the sample, the addition of ZIF-8@Asp NPs to the PLA nanofibers displayed no adverse effect on the shape recovery properties. Finally, the hemolysis and platelet adhesion confirmed that the surface of the ZIF-8@Asp-loaded PLA nanofibrous samples exhibited appropriate hemocompatibility.

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  Cite this article

[IEEE Style]

F. S. Chashmi, M. Khakbiz, P. Zahedi, M. Kabiri, "Poly(lactic acid) Nanofibrous Scaffolds Containing Aspirin-loaded Zeolitic Imidazolate Frameworks: Morphology, Drug Release, Hemocompatibility and Shape Memory Studies," Fibers and Polymers, vol. 23, no. 8, pp. 2103-2113, 2022. DOI: 10.1007/s12221-022-4163-7.

[ACM Style]

Fatemeh Salahi Chashmi, Mehrdad Khakbiz, Payam Zahedi, and Mahboubeh Kabiri. 2022. Poly(lactic acid) Nanofibrous Scaffolds Containing Aspirin-loaded Zeolitic Imidazolate Frameworks: Morphology, Drug Release, Hemocompatibility and Shape Memory Studies. Fibers and Polymers, 23, 8, (2022), 2103-2113. DOI: 10.1007/s12221-022-4163-7.

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pISSN : 1229 - 9197
eISSN : 1875 - 0052

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