Curcumin-loaded Polycaprolactone/Collagen Composite Fibers as Potential Antibacterial Wound Dressing 


Vol. 23,  No. 11, pp. 2994-3001, Nov.  2022
10.1007/s12221-022-4275-0


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  Abstract

The development of wound dressings with therapeutical benefits is of great importance in skin tissue engineering applications, adding bioactive molecules into biomaterials is a strategy to achieve a better biological response. In this study, four different concentrations of curcumin (CUR; 5, 10, 15 and 20 by weight in relation to the PCL content) were incorporated into solutions composed of polycaprolactone (PCL) and collagen (COL) for the manufacture of electrospun fibers. The PCLCOL- CUR fibers were physicochemically characterized in terms of their morphology, wettability, degradation rate, mechanical behavior, and cumulative curcumin release. The in vitro biological properties of the composite membranes were also evaluated. The results indicated that the membranes have diameters on average of approximately 200 nm. The water uptake was adequate for exudates remotion in a wound, and the degradation rate of the fibers was highly appropriate to achieve complete skin tissue regeneration. The addition of CUR to composite membranes produced a significant increase in the mechanical properties which indicate a satisfactory clinical handling. The incorporation of CUR produced a significant decrease in the planktonic growth of S. aureus over time, however, the antibacterial effect against E. coli was limited, the presence of CUR did not cause the inhibition of its growth. Finally, the viability of human dermal fibroblasts seeded on the top of the membranes indicated the cytotoxic dosage effect of CUR, the two highest CUR concentrations produced a significant loss of cell viability. Overall, our results suggested that the CUR-loaded PCL-COL composite membranes are promising candidates for use as antibacterial dressings to enhance clinical wound management.

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  Cite this article

[IEEE Style]

E. S. Mart, "Curcumin-loaded Polycaprolactone/Collagen Composite Fibers as Potential Antibacterial Wound Dressing," Fibers and Polymers, vol. 23, no. 11, pp. 2994-3001, 2022. DOI: 10.1007/s12221-022-4275-0.

[ACM Style]

E. San Mart. 2022. Curcumin-loaded Polycaprolactone/Collagen Composite Fibers as Potential Antibacterial Wound Dressing. Fibers and Polymers, 23, 11, (2022), 2994-3001. DOI: 10.1007/s12221-022-4275-0.

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pISSN : 1229 - 9197
eISSN : 1875 - 0052

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