Fabrication of Endothelial Cell-Lining Polyurethane/Polycaprolactone Tubular Scaffold Coated with Conjugated Linoleic Acid for Small-Diameter Vascular Graft 


Vol. 24,  No. 2, pp. 423-432, Feb.  2023
10.1007/s12221-023-00096-w


  Abstract

Artificial vascular transplantation is one of the potential state-of-the-art therapies for cardiovascular diseases, which are known as a leading cause of death worldwide. With the development of vascular tissue engineering, researchers have succeeded in creating large-caliber vascular structures. However, the challenges of fabricating artificial blood vessels less than 6 mm in diameter remain unsolved. In this study, we fabricated tubular structures of this size from blended polyurethane/ polycaprolactone nanofibers coated with anti-thrombogenic agents and lined with endothelial cells. The polymeric structure from those two cytocompatible polymers demonstrated suitable physical properties as a vascular graft. Further investigation on cell-material interaction with bovine artery endothelial cells established that the conjugated linoleic acid-grafted scaffold supported monolayer endothelial proliferation while limiting platelet adhesion. This approach could pave a way for developing a promising therapeutic method of artificial vascular transplantation that effectively overcomes occlusion.

  Statistics
Cumulative Counts from November, 2022
Multiple requests among the same browser session are counted as one view. If you mouse over a chart, the values of data points will be shown.


  Cite this article

[IEEE Style]

B. T. Vu, P. D. Nguyen, N. M. Tran, T. Tang, T. M. Do, T. V. Vo, H. T. Nguyen, "Fabrication of Endothelial Cell-Lining Polyurethane/Polycaprolactone Tubular Scaffold Coated with Conjugated Linoleic Acid for Small-Diameter Vascular Graft," Fibers and Polymers, vol. 24, no. 2, pp. 423-432, 2023. DOI: 10.1007/s12221-023-00096-w.

[ACM Style]

Binh Thanh Vu, Phuc Dang멞goc Nguyen, Nam Minh멠huong Tran, Tuan멞gan Tang, Thai Minh Do, Toi Van Vo, and Hiep Thi Nguyen. 2023. Fabrication of Endothelial Cell-Lining Polyurethane/Polycaprolactone Tubular Scaffold Coated with Conjugated Linoleic Acid for Small-Diameter Vascular Graft. Fibers and Polymers, 24, 2, (2023), 423-432. DOI: 10.1007/s12221-023-00096-w.

Search
(IN TITLE, AUTHOR, ABSTRACT,KEYWORDS)

Advanced Search ▼

POPULAR KEYWORDS
(TOP 10 KEYWORDS)

Recent Publications
(LAST 3 YEARS)

pISSN : 1229 - 9197
eISSN : 1875 - 0052

Impact Factor(2022): 2.5