Fabrication of Acorn-Loaded Chitosan/Gelatin Nanofibrous Web to Increase Antibacterial Activity for Wound-Healing Applications 


Vol. 24,  No. 3, pp. 893-906, Mar.  2023
10.1007/s12221-023-00043-9


PDF
  Abstract

A biocompatible nanofi brous scaff old incorporated with the antibacterial extract of medicinal plant has a synergic eff ect on the process of wound healing, which is due to its high surface area to volume ratio and mimicking the natural extracellular matrix (ECM) of nanofi brous structure, in addition to lower side eff ects and antibiotic resistance. Here, biocompatible nanofi bers of (chitosan:gelatin)/poly(vinyl alcohol)(PVA) were prepared through electrospinning with acorn extract as a natural cross-linker and antibacterial agent for wound-healing applications. The morphology of nanofi bers containing various amounts of acorn extract [0.5%, 1%, and 1.5% (w/v)] was investigated by SEM images. The chemical composition of nanofi bers was investigated by FTIR spectra. The tensile testing demonstrated the enhancement of mechanical properties of nanofi brous webs (up to 118% tensile stress, 117% young modulus, and 77% strain at break) by adding acorn extract. The degradation rate and the acorn release rate of cross-linked nanofi bers decreased by increasing acorn concentration acting as a natural cross-linker. The release mechanism of cross-linked nanofi bers was non-Fickian diff usion for 0.5% acorn loading and Fickian diff usion for 1% and 1.5% acorn loading. The acorn-loaded nanofi bers showed a 90% antibacterial activity against Staphylococcus aureus bacterium by quantitative standard test method (AATCC 100). Furthermore, the MTT assay showed excellent cell viability and cell attachment of nanofi bers for mouse fi broblast (L929) cells. The results indicated that (chitosan:gelatin)/PVA nanofi brous scaff old incorporated with acorn extract was a potent candidate for tissue engineering applications.

  Statistics
Cumulative Counts from November, 2022
Multiple requests among the same browser session are counted as one view. If you mouse over a chart, the values of data points will be shown.


  Cite this article

[IEEE Style]

E. Hadipour-Goudarzi, N. hemmatinejad, M. A. Shokrgozar, "Fabrication of Acorn-Loaded Chitosan/Gelatin Nanofibrous Web to Increase Antibacterial Activity for Wound-Healing Applications," Fibers and Polymers, vol. 24, no. 3, pp. 893-906, 2023. DOI: 10.1007/s12221-023-00043-9.

[ACM Style]

Elmira Hadipour-Goudarzi, Nahid hemmatinejad, and Mohammad Ali Shokrgozar. 2023. Fabrication of Acorn-Loaded Chitosan/Gelatin Nanofibrous Web to Increase Antibacterial Activity for Wound-Healing Applications. Fibers and Polymers, 24, 3, (2023), 893-906. DOI: 10.1007/s12221-023-00043-9.

Search
(IN TITLE, AUTHOR, ABSTRACT,KEYWORDS)

Advanced Search ▼

POPULAR KEYWORDS
(TOP 10 KEYWORDS)

Recent Publications
(LAST 3 YEARS)

pISSN : 1229 - 9197
eISSN : 1875 - 0052

Impact Factor(2022): 2.5