Modifying Porous Bacterial Cellulose with Chondroitin Sulfate/Gelatin for Improved Biocompatibility 


Vol. 24,  No. 3, pp. 975-984, Mar.  2023
10.1007/s12221-023-00036-8


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  Abstract

Lacking large pores and insuffi cient bioactivity are two critical disadvantages of bacterial cellulose (BC). In this study, a new type of coating, chondroitin sulfate (CS) modifi ed with gelatin (Gel), was selected to modify porous bacterial cellulose (PBC) for improved biocompatibility. The PBC was fabricated by adding Gel microspheres in the culture medium of BC, and the PBC-CS/Gel scaff olds were prepared by immersing PBC in the CS solutions followed by Gel modifi cation. The morphology, chemical structure, physicochemical properties, and in vitro cell behavior of the PBC-CS/Gel scaff olds were characterized. The mechanical test shows that the tensile strength and Young's modulus of the PBC scaff old were increased with the introduction of CS/Gel coatings. The in vitro cell studies show that the CS/Gel coatings signifi cantly promote cell proliferation, adhesion, diff erentiation, and ingrowth into scaff olds. The PBC-CS/Gel scaff olds are expected to be used in tissue engineering.

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  Cite this article

[IEEE Style]

H. Luo, C. Yin, B. Zhong, W. Li, Z. Yang, H. Zhu, Y. Zhan, X. Cai, K. Ren, Q. Zhang, Y. Wan, "Modifying Porous Bacterial Cellulose with Chondroitin Sulfate/Gelatin for Improved Biocompatibility," Fibers and Polymers, vol. 24, no. 3, pp. 975-984, 2023. DOI: 10.1007/s12221-023-00036-8.

[ACM Style]

Honglin Luo, Cheng Yin, Bingbing Zhong, Wei Li, Zhiwei Yang, Hongmin Zhu, Yuliang Zhan, Xinyong Cai, Kaijing Ren, Quanchao Zhang, and Yizao Wan. 2023. Modifying Porous Bacterial Cellulose with Chondroitin Sulfate/Gelatin for Improved Biocompatibility. Fibers and Polymers, 24, 3, (2023), 975-984. DOI: 10.1007/s12221-023-00036-8.

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pISSN : 1229 - 9197
eISSN : 1875 - 0052

Impact Factor(2022): 2.5