An Integrated Micro-nano-fibrous Bilayered Small-Diameter Vascular Graft Simultaneously Supporting Endothelial and Smooth Muscle Cells 


Vol. 24,  No. 4, pp. 1211-1224, Apr.  2023
10.1007/s12221-023-00155-2


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  Abstract

A good vascular graft should have a biomimetic integrated layered structure and simultaneously facilitate the formation of endothelial cell monolayer and proliferation of vascular smooth muscle cells (SMCs). Herein, we report an integrated bilayered small-diameter vascular graft consisting of a dense inner layer of bacterial cellulose (BC) nanofi bers and saponifi ed cellulose acetate (SCA) microfi bers and a macroporous outer layer of BC. The integrated bilayered graft is fabricated by a combined method of electrospinning, in situ biosynthesis, and laser ablation. Scanning electron microscopy (SEM) analysis confi rms that the BC nanofi bers run through the inner and outer layers, leading to an integrated bilayered graft, and average pore size in the outer layer is 225.4 關m. In case of the integrated structure, the bilayered graft shows the suture retention of 0.68 N and 0.54 N in the dried and wet states, respectively. In vitro hemocompatibility experiments show that the BC/SCA inner layer exhibits good hemocompatibility. Furthermore, the compact micro-nano-fi brous inner layer favors endothelialization, while the macroporous outer layer promotes growth and proliferation of SMCs, thus achieving control over specifi c cellular behavior in respective layers. The unique integrated bilayered vascular graft exhibits the required mechanics, good hemocompatibility and biocompatibility and thus holds great promise for use as a blood vessel substitute.

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  Cite this article

[IEEE Style]

Q. Zhang, M. Zhang, M. Wang, Z. Song, H. Luo, Z. Yang, Y. Wan, "An Integrated Micro-nano-fibrous Bilayered Small-Diameter Vascular Graft Simultaneously Supporting Endothelial and Smooth Muscle Cells," Fibers and Polymers, vol. 24, no. 4, pp. 1211-1224, 2023. DOI: 10.1007/s12221-023-00155-2.

[ACM Style]

Quanchao Zhang, Mengna Zhang, Ming Wang, Zhiqiang Song, Honglin Luo, Zhiwei Yang, and Yizao Wan. 2023. An Integrated Micro-nano-fibrous Bilayered Small-Diameter Vascular Graft Simultaneously Supporting Endothelial and Smooth Muscle Cells. Fibers and Polymers, 24, 4, (2023), 1211-1224. DOI: 10.1007/s12221-023-00155-2.

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pISSN : 1229 - 9197
eISSN : 1875 - 0052

Impact Factor(2022): 2.5