Performance Evaluation of Poly (ɛ-Caprolactone)/Cellulose Acetate Nanofibrous Scaffold Containing Graphene Oxide used for Neural Tissue Regeneration Potentially 


Vol. 24,  No. 7, pp. 2293-2303, Jul.  2023
10.1007/s12221-023-00231-7


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  Abstract

A novel electroactive biocompatible nanofi brous scaff old based on poly (ε-caprolactone) (PCL)/cellulose acetate (CA) containing graphene oxide (GO) is prepared by the use of electrospinning, which is employed for neural tissue regeneration potentially. By varying GO content, the PCL/CA nanofibers including 0.5 wt. % of GO is chosen as an optimum sample with an average diameter of approximately 280 nm and electrical conductivity of around 75 μS/m. According to the functional group analysis, no chemical reaction occurred during the physical distribution of GO within the PCL/CA nanofibers. Subsequently, the wetting and mechanical properties of the optimized sample reported a water contact angle of 39 and a tensile strength of 2.5 MPa, respectively. Moreover, the electrical activity of the PCL/CA nanofibers containing 0.5 wt. % of GO is higher than that of without GO based on cyclic voltammetry. Finally, the cell viability, adhesion, and differentiation of PCL/CA-0.5GO nanofibrous scaffold are shown that the presence of GO leads to providing a susceptible medium for living the cells, highly spread cells alongside tight adhesion as well as remarkable cell differentiation with their deep diffusion in the interlayers of the nanofibrous scaffold.

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  Cite this article

[IEEE Style]

E. Ahmadi, P. Harirchi, P. Zahedi, B. Bakhshandeh, S. Zolfagharian, A. Khatibi, "Performance Evaluation of Poly (ɛ-Caprolactone)/Cellulose Acetate Nanofibrous Scaffold Containing Graphene Oxide used for Neural Tissue Regeneration Potentially," Fibers and Polymers, vol. 24, no. 7, pp. 2293-2303, 2023. DOI: 10.1007/s12221-023-00231-7.

[ACM Style]

Elham Ahmadi, Parmida Harirchi, Payam Zahedi, Behnaz Bakhshandeh, Shadi Zolfagharian, and Alireza Khatibi. 2023. Performance Evaluation of Poly (ɛ-Caprolactone)/Cellulose Acetate Nanofibrous Scaffold Containing Graphene Oxide used for Neural Tissue Regeneration Potentially. Fibers and Polymers, 24, 7, (2023), 2293-2303. DOI: 10.1007/s12221-023-00231-7.

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pISSN : 1229 - 9197
eISSN : 1875 - 0052

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