Study on Preparation of Core-Spun Yarn Surgical Sutures by Compositing Drug-Loaded Nanofiber Membrane with PLA and Its Controllable Drug Release Performance 


Vol. 24,  No. 12, pp. 4181-4193, Dec.  2023
10.1007/s12221-023-00386-3


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  Abstract

Polylactic acid (PLA) surgical suture is considered to be one of the most ideal materials for tissue closure due to its rich raw materials and excellent biological properties. However, surgical sutures face great challenges due to problems such as wound infection and tissue reaction in practical applications. In order to improve the clinical applicability of surgical sutures, we constructed a new drug-loading system for core-spun surgical sutures. The shell was composed of nanofibrous membranes composed of polyglycolic acid (PGA) and polycaprolactone (PCL) and ciprofloxacin (CIP) antibacterial drugs, and the core layer adopts PLA filament. By adjusting the composition ratio of PGA and PCL in the shell, a new mode of regulating the release rate and release cycle of the suture was constructed. According to different wound healing time, different drug release cycles of surgical suture were selected. In the study, the structure of the core-spun yarn can be clearly observed by scanning electron microscope, the higher the shell PGA content and drug loading, the faster the drug release rate. When the carrier ratio PGA/PCL was 80/20 and the drug loading was 3%, the drug release rate was the fastest and the drug release was high; finally, antibacterial experiments showed that the suture had excellent antibacterial effect and could effectively kill Staphylococcus aureus and Escherichia coli. The successful preparation of core-spun yarn surgical suture provides a new idea for the study of new antibacterial surgical suture.

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  Cite this article

[IEEE Style]

Z. Yang, S. Liu, J. Li, G. Wu, M. Zhang, F. Li, L. Jia, Y. Zhang, H. Li, X. Liu, J. Zhao, H. Zhang, S. Li, "Study on Preparation of Core-Spun Yarn Surgical Sutures by Compositing Drug-Loaded Nanofiber Membrane with PLA and Its Controllable Drug Release Performance," Fibers and Polymers, vol. 24, no. 12, pp. 4181-4193, 2023. DOI: 10.1007/s12221-023-00386-3.

[ACM Style]

Zhichao Yang, Shuqiang Liu, Jingjing Li, Gaihong Wu, Man Zhang, Fu Li, Lu Jia, Yujing Zhang, Huimin Li, Xia Liu, Jingjing Zhao, Huiqin Zhang, and Shiyu Li. 2023. Study on Preparation of Core-Spun Yarn Surgical Sutures by Compositing Drug-Loaded Nanofiber Membrane with PLA and Its Controllable Drug Release Performance. Fibers and Polymers, 24, 12, (2023), 4181-4193. DOI: 10.1007/s12221-023-00386-3.

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pISSN : 1229 - 9197
eISSN : 1875 - 0052

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