Electrically Conductive Polypyrrole@keratin Nanofiber Membranes with Potential for Tissue Restoration 


Vol. 25,  No. 3, pp. 751-763, Mar.  2024
10.1007/s12221-023-00439-7


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  Abstract

lectrical stimulation with conductive biomaterials shows great promising to promote skin wound healing in practical application. In this study, polypyrrole@keratin nanofiber membrane (PPy@KNM) with good conductivity was prepared using electrospinning technology and chemical in situ polymerization of pyrrole monomers. Morphological, chemical, X-ray and surface analyses suggested that PPy was deposited on the keratin nanofiber membrane (KNM). The PPy@KNM with the highest conductivity and the largest tensile strength was prepared with an oxidant concentration of 0.6 M and a dopant concentration of 0.5 M of the p-toluenesulfonic acid (p-TSA). In vitro cell culture experiments revealed that the conductive PPy@KNM performed good biocompatibility and no cytotoxicity. Electrical stimulation via the PPy@KNM can reasonably accelerate cell growth and cell proliferation with an optimal current intensity of 80 μA and a stimulation time of 5 min/d. The research outcomes demonstrated that PPy@KNM is suitable to be applied as a functional biomedical material to promote wound healing.

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  Cite this article

[IEEE Style]

L. Zhang, Y. Ma, T. Lei, X. Yang, L. Zhang, Y. Wang, J. Liu, X. Li, Q. Yang, S. He, J. Fan, "Electrically Conductive Polypyrrole@keratin Nanofiber Membranes with Potential for Tissue Restoration," Fibers and Polymers, vol. 25, no. 3, pp. 751-763, 2024. DOI: 10.1007/s12221-023-00439-7.

[ACM Style]

Li Zhang, Yaqian Ma, Tongda Lei, Xue Yang, Li Zhang, Yongheng Wang, Jianhua Liu, Xipeng Li, Qingqi Yang, Sen He, and Jie Fan. 2024. Electrically Conductive Polypyrrole@keratin Nanofiber Membranes with Potential for Tissue Restoration. Fibers and Polymers, 25, 3, (2024), 751-763. DOI: 10.1007/s12221-023-00439-7.

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pISSN : 1229 - 9197
eISSN : 1875 - 0052

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