Poly(N-vinyl caprolactam-co-maleic anhydride)-Grafted Cotton Gauze with Antimicrobial Properties for Their Potential Use as Wound Dressings 


Vol. 25,  No. 3, pp. 933-943, Mar.  2024
10.1007/s12221-024-00490-y


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  Abstract

Medical cotton gauzes were modified by grafting poly(N-vinylcaprolactam-co-maleic anhydride) (gauze-g-(PVCL-co-MA)) through free radical polymerization to prepare a novel wound dressing with antimicrobial and drug delivery capabilities. Several gauze-g-(PVCL-co-MA) were synthesized, each characterized by distinct grafting percentage of 23, 40, and 100% labeled as VMG1, VMG2, and VMG3, respectively. Polymer grafting was verified using methods such as Fourier Transform Infrared Spectroscopy (FT-IR), Thermogravimetric analysis (TGA), Scanning Electronic Microscopy (SEM), and swelling studies. The grafted cotton gauzes were loaded with vancomycin and tested as drug-eluting systems, exhibited considerable loading capacity and over 80% release. The antibacterial activity was evaluated against S. aureus (ATCC 29213) according to the Japanese Industrial Standard JIS Z 2801 method. They showed growth inhibition for this microorganism. Moreover, they showed good biocompatibility for the 1132SK and SaOS-2 cell lines. These results suggest that the gauze-g-(PVCL-co-MA) could be used as antimicrobial and drug-eluting wound dressings in the biomedical field

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  Cite this article

[IEEE Style]

J. Carrillo-Rodríguez, .. Betancourt-Galindo, J. C. Carrillo-Rodríguez, H. I. Meléndez-Ortiz, B. Puente-Urbina, R. Espinosa-Neira, A. Ledezma, "Poly(N-vinyl caprolactam-co-maleic anhydride)-Grafted Cotton Gauze with Antimicrobial Properties for Their Potential Use as Wound Dressings," Fibers and Polymers, vol. 25, no. 3, pp. 933-943, 2024. DOI: 10.1007/s12221-024-00490-y.

[ACM Style]

J. Carrillo-Rodríguez, . Betancourt-Galindo, J. C. Carrillo-Rodríguez, H. Ivan Meléndez-Ortiz, B. Puente-Urbina, R. Espinosa-Neira, and A. Ledezma. 2024. Poly(N-vinyl caprolactam-co-maleic anhydride)-Grafted Cotton Gauze with Antimicrobial Properties for Their Potential Use as Wound Dressings. Fibers and Polymers, 25, 3, (2024), 933-943. DOI: 10.1007/s12221-024-00490-y.

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pISSN : 1229 - 9197
eISSN : 1875 - 0052

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