The Risk Assessment of Runway Reaction in the Process of Fridel –Crafts Acylation for Synthesis Reaction 


Vol. 36,  No. 3, pp. 24-30, Jun.  2021
10.14346/JKOSOS.2021.36.3.24


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  Abstract

Heat is generated during the synthesis and mixing process of chemical compounds due to a change in activation energy during the reaction. A runaway reaction occurs when sufficient heat is not removed during the heat control process within a reactor, rapidly increasing the temperature, reaction speed, and rate of heat generation inside the reactor. A risk assessment was executed using an RC-1 (Reaction Calorimeter) during Friedel-Crafts acylation. Friedel-Crafts acylation runs the risk of rapid heat generation during Active Pharmaceutical Ingredient (API) manufacturing; it was used to confirm the risk of a runaway reaction at each synthesis stage and during the mixing process. This study used experimental data to develop a safety efficiency improvement plan to control the risks of runaway and other exothermic reactions, which was implemented at the production site of a chemical plant.

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  Cite this article

[IEEE Style]

이광호, 김원성, 전진우, 주영종, 박교식, "The Risk Assessment of Runway Reaction in the Process of Fridel –Crafts Acylation for Synthesis Reaction," Journal of the Korean Society of Safety, vol. 36, no. 3, pp. 24-30, 2021. DOI: 10.14346/JKOSOS.2021.36.3.24.

[ACM Style]

이광호, 김원성, 전진우, 주영종, and 박교식. 2021. The Risk Assessment of Runway Reaction in the Process of Fridel –Crafts Acylation for Synthesis Reaction. Journal of the Korean Society of Safety, 36, 3, (2021), 24-30. DOI: 10.14346/JKOSOS.2021.36.3.24.

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