Fabrication and Properties of Electrospun Double-Layered Nanofibrous Membranes for Guided Bone Regeneration 


Vol. 62,  No. 6, pp. 376-383, Dec.  2025
10.12772/TSE.2025.62.376


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  Abstract

Guided bone regeneration (GBR) is a surgical technique that promotes bone formation by using a barrier membrane during implant placement or in cases of alveolar bone defects. The membrane prevents the infiltration of rapidly proliferating fibrous connective and epithelial tissues while providing a physical space for osteogenic cell growth. However, conventional membranes often exhibit hydrophobic properties, which limit cell adhesion and proliferation. To address this limitation, a hydrophilic nanofibrous barrier layer was fabricated by electrospinning a blend of biodegradable poly(ε-caprolactone) (PCL) and hydrophilic polyvinylpyrrolidone (PVP). Subsequently, to ensure sufficient mechanical integrity, a double-layered nanofibrous membrane was prepared by electrospinning a PCL/poly(glycolic acid) (PGA) solution. The membranes were characterized by attenuated total reflectance–Fourier transform infrared spectroscopy (ATR-FTIR) and scanning electron microscopy (SEM). Surface hydrophilicity was evaluated via water contact angle (WCA) measurements, mechanical properties were analyzed using a universal testing machine (UTM), and cytocompatibility was assessed through a lactate dehydrogenase (LDH) assay based on extract testing. The PCL/PVP layer exhibited a tensile strength below 1 MPa, which increased to 8.62 MPa after forming the double-layered structure. All samples demonstrated over 70% cell viability in the LDH-based cytotoxicity test, confirming the potential of the developed membranes as biodegradable barrier materials for guided bone regeneration.

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[IEEE Style]

이경태, 허소윤, 홍영기, "Fabrication and Properties of Electrospun Double-Layered Nanofibrous Membranes for Guided Bone Regeneration," Textile Science and Engineering, vol. 62, no. 6, pp. 376-383, 2025. DOI: 10.12772/TSE.2025.62.376.

[ACM Style]

이경태, 허소윤, and 홍영기. 2025. Fabrication and Properties of Electrospun Double-Layered Nanofibrous Membranes for Guided Bone Regeneration. Textile Science and Engineering, 62, 6, (2025), 376-383. DOI: 10.12772/TSE.2025.62.376.

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pISSN : 1225 - 1089
eISSN : 2288 - 6419

한국연구재단 우수등재학술지 유지 (2022년)