Preparation of Electrospun Alginate Webs for Transdermal Drug Delivery Systems 


Vol. 52,  No. 1, pp. 14-19, Feb.  2015
10.12772/TSE.2015.52.014


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  Abstract

In this study, alginate was electrospun for transdermal drug delivery systems. The spinnability of alginate was improved by the reduction of intra-molecular hydrogen bonding using glycerol. The prepared alginate solutions were electrospun and coagulated in CaCl2 aqueous solution for improved dimensional stability. To observe release ability, the electrospun alginate web was immersed in phosphate buffered saline (PBS) solution. Although 60% of dextran (drug model) was released from the prepared web within 30 minutes, the remaining drug was released continuously over 3 days. The results indicated that the prepared alginate web could be used as a transdermal drug delivery system.

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pISSN : 1225 - 1089
eISSN : 2288 - 6419

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