Biodegradable Chitosan/PLGA/Polysorbate80 Nanofibrous Mat Fabrication and Application to Tissue-adhesion Barriers

In the field of surgery, several instances of adhesions in the abdomen, bowel, uterus, and pelvis are observed. Severe post-operative adhesions cause pain in the pelvis and bowel, infertility, and intestinal obstruction. Despite much interest in preventing postoperative adhesion, these symptoms appear persistently. In this study, various composition of chitosan and PLGA blend nanofibrous sheets containing a small quantity of nonionic surfactant, polysorbate80 were fabricated by electrospining technique for application to anti-adhesion barrier. The average diameter of fabricated nanofibers as determined by SEM ranged between 100 to 130 nm. Surface hydrophilicity and biodegradability of nanofibrous mats increased with increasing chitosan content. However, cell attachment and proliferation on nanofibrous surfaces were decreased with increasing chitosan content, probably due to enhanced hydrophilicity. In vivo animal test confirmed that the Chitosan/PLGA(5:5)/Polysorbate80 nanofibrous sheet was sufficiently effective, than the PLGA nanofibrous sheet, in preventing undesired tissue adhesion.

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Biodegradable Chitosan/PLGA/Polysorbate80 Nanofibrous Mat Fabrication and Application to Tissue-adhesion Barriers

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