HA-PLGA Nanoparticle-Incorporated Gelatin Nanofibers for Transdermal Drug Delivery

In recent years, transdermal drug delivery system (TDDS) has emerged as an alternative to needle injection. TDDS offers various benefits including being noninvasive and encouraging patient compliance; however, the skin barrier, stratum corneum, prevents sufficient penetration of drugs through the skin. In this work, we have designed hyaluronic acid-poly(lactic-co-glycolic acid) nanoparticle (HA-PLGA NP)-incorporated gelatin nanofiber (GE NF/HA-PLGA) complexes for the sustained release of drugs and to avoid drug degradation in TDDS. The HA-PLGA NPs were prepared by water-in-oil-inwater (W/O/W) solvent evaporation method, while the GE NFs were fabricated by electrospinning. The successful formation of HA-PLGA NPs were confirmed by proton nuclear magnetic resonance, transmission electron microscopy, and dynamic light scattering, while that of the NFs were confirmed by field emission scanning electron microscopy and Fourier-transform infrared spectroscopy. The results of in vitro release tests reveal that the GE/HA-PLGA complex shows delayed and extended release of drugs. The histological analysis demonstrates that the HA-PLGA NPs can be released from the GE NFs and penetrate the skin. These results indicate the feasibility of using GE/HA-PLGA complexes as a suitable candidate for novel TDDS.

Statistics

Cumulative Counts from November, 2022
Multiple requests among the same browser session are counted as one view. If you mouse over a chart, the values of data points will be shown.

HA-PLGA Nanoparticle-Incorporated Gelatin Nanofibers for Transdermal Drug Delivery

Submenu

Search
(IN TITLE, AUTHOR, ABSTRACT,KEYWORDS)

Advanced Search

Recent Publications
(LAST 3 YEARS)