HA-PLGA Nanoparticle-Incorporated Gelatin Nanofibers for Transdermal Drug Delivery
Vol. 56, No. 3, pp. 155-161,
Jun. 2019
10.12772/TSE.2019.56.155
PDF
Abstract
In recent years, transdermal drug delivery system (TDDS) has emerged as an
alternative to needle injection. TDDS offers various benefits including being noninvasive
and encouraging patient compliance; however, the skin barrier, stratum corneum,
prevents sufficient penetration of drugs through the skin. In this work, we have designed
hyaluronic acid-poly(lactic-co-glycolic acid) nanoparticle (HA-PLGA NP)-incorporated
gelatin nanofiber (GE NF/HA-PLGA) complexes for the sustained release of drugs and to
avoid drug degradation in TDDS. The HA-PLGA NPs were prepared by water-in-oil-inwater
(W/O/W) solvent evaporation method, while the GE NFs were fabricated by
electrospinning. The successful formation of HA-PLGA NPs were confirmed by proton
nuclear magnetic resonance, transmission electron microscopy, and dynamic light
scattering, while that of the NFs were confirmed by field emission scanning electron
microscopy and Fourier-transform infrared spectroscopy. The results of in vitro release
tests reveal that the GE/HA-PLGA complex shows delayed and extended release of drugs.
The histological analysis demonstrates that the HA-PLGA NPs can be released from the
GE NFs and penetrate the skin. These results indicate the feasibility of using GE/HA-PLGA
complexes as a suitable candidate for novel TDDS.
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