Production of Collagen Nanofiber Using Electrospinning Dope of Acid-soluble Collagen Isolated from Fish Skin
Vol. 57, No. 3, pp. 186-191,
Jun. 2020
10.12772/TSE.2020.57.186
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Abstract
Collagen is a natural, biocompatible, and biodegradable material with low
immunogenicity, which is useful for tissue and organ formation and in multiple cellular
functions. Moreover, Type I collagen is known to be a suitable material for medical applications.
In this study, acid-soluble Type I collagen isolated from fish skin was used to make
nanofibers through electrospinning using a high concentration of collagen solutions prepared
by dissolving the collagen to 18 wt% in 20 wt% acetic acid at 20 °C. The collagen and
collagen nanofiber were Type I collagen subjected to sodium dodecyl sulfate-polyacrylamide
gel electrophoresis analysis. The nonaqueous collagen nanofiber was heat-treated,
which yielded a chemical crosslinking agent, such as polyacrylic acid, besides collagen.
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