Synthesis and Drug Release Property of Poly(ethylene glycol-block-L-lactide-block-N-isopropylacrylamide) Triblock Copolymer
Vol. 57, No. 5, pp. 247-254,
Oct. 2020
10.12772/TSE.2020.57.247
PDF
Abstract
Herein, novel linear block copolymers have been synthesized for use as a drugeluting
coating material in vascular grafts. Poly(ethylene glycol-block-L-lactide-block-N-isopropylacrylamide)
triblock copolymers were prepared by stepwise polymerization from
methoxy-terminated polyethylene glycol, i.e., anionic ring-opening polymerization of L-lactide
followed by quasi-living polymerization of N-isopropylacrylamide. The chemical structures
of the triblock copolymers were analyzed by FT-IR spectroscopy, ¹H-NMR
spectroscopy, and WAXD. The surface adhesion of triblock copolymers was evaluated for
the substrate and model proteins. The drug release behavior of antiproliferative methotrexate
was investigated according to the block ratio of the triblock copolymers. Viscosity
increased significantly with increasing proportion of poly(N-isopropylacrylamide) block,
whereas protein adhesion decreased with decreasing proportion of poly(L-lactide) block.
Furthermore, methotrexate release increased with decreasing proportion of poly(L-lactide)
block, and both the initial and sustained release increased with increasing proportion of
poly(N-isopropyl acrylamide) block. This triblock copolymer can adjust the ratio of blocks
to design effective drug release for specific applications.
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