Synthesis and Functionalization of PLA-Knitted Fabrics with Silk Fibroin Nanoparticles and Chitosan: Evaluation of Cytotoxicity and Cell Adhesion 


Vol. 25,  No. 10, pp. 3751-3764, Oct.  2024
10.1007/s12221-024-00690-6


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  Abstract

The substance principal used to synthesize these materials is fbroin, obtained from the silkworm’s cocoon (Bombyx mori) in the form of a flament, but can be converted into nanometric particles. After the synthesis, the obtained samples were characterized by size and Zeta potential (via nanosizer), X-Ray difraction (XRD), specifc area determination by the BET method, Infrared Spectroscopy with Fourier Transform with attenuated difuse refectance (FTIR), transmission electron microscopy (TEM). The silk fbroin nanoparticles (SFNp) were immobilized on polylactic acid (PLA)-knitted fabric and functionalized with chitosan for FTIR and XRD analyses, in addition to cytotoxicity analysis with colorimetric test (MTT) and cell adhesion. The DLS, FTIR and MET results confrm the formation of spherical silk fbroin nanoparticles with average sizes between 48 and 156nm, and zeta potential of − 19.95mV which characterizes a good dispersibility. Cell-viability assessment showed that SFNp is a non-cytotoxic material at low concentrations up to 48h, confrming that the nanoparticle synthesis method using the ternary system is an efective and low-cost alternative. This technique has great potential for use in the development of biomaterials, due to the production of knitted tissues with PLA functionalized with chitosan and immobilized with SFNp, exhibiting mechanical strength and biocompatibility.

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  Cite this article

[IEEE Style]

R. Almeida, R. P. S. Pontes, M. K. P. Ferreira, P. B. Borba, A. L. d. Sá, V. F. d. A. Neto, T. F. d. Santos, R. L. J. Almeida, J. H. O. d. Nascimento, "Synthesis and Functionalization of PLA-Knitted Fabrics with Silk Fibroin Nanoparticles and Chitosan: Evaluation of Cytotoxicity and Cell Adhesion," Fibers and Polymers, vol. 25, no. 10, pp. 3751-3764, 2024. DOI: 10.1007/s12221-024-00690-6.

[ACM Style]

Raphael Almeida, Rayana Priscilla Silva Pontes, Myllena Kely Pereira Ferreira, Pedro Brito Borba, Andrea Lima de Sá, Valter Ferreira de Andrade Neto, Thiago Félix dos Santos, Raphael Lucas Jacinto Almeida, and José Heriberto Oliveira do Nascimento. 2024. Synthesis and Functionalization of PLA-Knitted Fabrics with Silk Fibroin Nanoparticles and Chitosan: Evaluation of Cytotoxicity and Cell Adhesion. Fibers and Polymers, 25, 10, (2024), 3751-3764. DOI: 10.1007/s12221-024-00690-6.

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pISSN : 1229 - 9197
eISSN : 1875 - 0052

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