Synthesis and Characterization of Carboxymethyl Chitosan/Polyvinyl Alcohol Containing Zinc Oxide Nanoparticles as Hydrogel Wound Dressing 


Vol. 25,  No. 11, pp. 4199-4213, Nov.  2024
10.1007/s12221-024-00748-5


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  Abstract

In the biomedical field, hydrogels are extensively utilized due to their ability to provide mechanical support and create a moist environment for wounds. In this study, nanocomposite hydrogels containing carboxymethyl chitosan (CsMe), polyvinyl alcohol (PVA), and zinc oxide nanoparticles (ZnO-NPs) in different weight ratios (0, 0.5, 0.8, and 1.2%) were prepared for wound healing. The prepared hydrogels were analyzed using Fourier transform infrared spectroscopy (FTIR), field-emission scanning electron microscopy (FE-SEM), and X-ray diffraction (XRD). Additionally, the mechanical properties, swelling ratio, MTT assay, antibacterial efficacy, and in vivo wound healing were assessed. MTT assays indicated no toxicity after incorporating ZnO-NPs into the hydrogel, and the maximum antibacterial efficiencies of CsMe/PVA/ZnO-NPs (0.5%) hydrogels against E. coli and S. aureus were 91.85 ± 1.2% and 52.7 ± 0.84%, respectively. In vivo studies demonstrated that the hydrogel containing 0.5% ZnO-NPs significantly accelerated wound healing, with 96 ± 2.41% wound closure after 14 days, compared to 83.5 ± 6.76% for the group treated with commercial ZnO ointment. The results suggest that ZnO-NPs in hydrogels enhance antibacterial activity and promote better wound healing than traditional ZnO ointments, offering a promising material for advanced wound care applications.

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  Cite this article

[IEEE Style]

S. Kashanian, K. Bakhtiari, S. Kashanian, R. Mohamadinooripoor, K. Rashidi, S. Sajadimajd, K. Omidfar, "Synthesis and Characterization of Carboxymethyl Chitosan/Polyvinyl Alcohol Containing Zinc Oxide Nanoparticles as Hydrogel Wound Dressing," Fibers and Polymers, vol. 25, no. 11, pp. 4199-4213, 2024. DOI: 10.1007/s12221-024-00748-5.

[ACM Style]

Soheila Kashanian, Kimia Bakhtiari, Soheila Kashanian, Rezvan Mohamadinooripoor, Khodabakhsh Rashidi, Soraya Sajadimajd, and Kobra Omidfar. 2024. Synthesis and Characterization of Carboxymethyl Chitosan/Polyvinyl Alcohol Containing Zinc Oxide Nanoparticles as Hydrogel Wound Dressing. Fibers and Polymers, 25, 11, (2024), 4199-4213. DOI: 10.1007/s12221-024-00748-5.

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pISSN : 1229 - 9197
eISSN : 1875 - 0052

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