Biodegradable PCL Hybrids with 6-Aminocoumarin: A Promising Material for Antimicrobial Implants and Tissue Engineering 


Vol. 26,  No. 12, pp. 5269-5281, Dec.  2025
10.1007/s12221-025-01172-z


PDF
  Abstract

Poly(ε-caprolactone) (PCL) is a biodegradable polyester widely used in biomedical applications due to its biocompatibility and tunable mechanical properties. However, its lack of inherent antimicrobial activity limits its utility in infection-prone settings. This study reports the covalent modification of PCL with 6-aminocoumarin (6-AMC) to create functional composites (PCL/6-AMC) with enhanced crystallinity, fluorescence, and antimicrobial properties. The composites were synthesized via solvent casting and characterized using XRD, FTIR, NMR, UV–Vis spectroscopy, and SEM. XRD analysis revealed that 6-AMC incorporation increased PCL crystallinity by up to 40%, while FTIR and NMR confirmed covalent bonding via aminolysis of PCL ester groups. UV–Vis spectra demonstrated successful 6-AMC integration, with a characteristic absorption peak at 400 nm. Antimicrobial assays against Staphylococcus aureus, Escherichia coli, Candida albicans, and Aspergillus niger showed dose-dependent activity, with PCL/6-AMC (6 wt.%) achieving 100% growth inhibition of S. aureus and E. coli. Cytotoxicity assays on human fetal lung fibroblasts (Wi38) confirmed biocompatibility for PCL and its PCL/6-AMC (IC50 ranged from 721.78, 1020.83, and 1143 µg/mL for PCL, PCL3/6-AMC, and PCL6/6-AMC, respectively). The composites combine PCL’s biodegradability with 6-AMC’s antimicrobial and fluorescent properties, offering potential for applications in drug delivery, tissue engineering, and antimicrobial coatings.

  Statistics
Cumulative Counts from November, 2022
Multiple requests among the same browser session are counted as one view. If you mouse over a chart, the values of data points will be shown.


  Cite this article

[IEEE Style]

M. Alanazi, S. Albalawi, A. Alharbi, S. A. Alqarni, A. I. Alalawy, A. Mogadem, R. M. S. Attar, N. M. El-Metwaly, "Biodegradable PCL Hybrids with 6-Aminocoumarin: A Promising Material for Antimicrobial Implants and Tissue Engineering," Fibers and Polymers, vol. 26, no. 12, pp. 5269-5281, 2025. DOI: 10.1007/s12221-025-01172-z.

[ACM Style]

Maer Alanazi, Shadiah Albalawi, Arwa Alharbi, Sara A. Alqarni, Adel I. Alalawy, Abeer Mogadem, Roba M. S. Attar, and Nashwa M. El-Metwaly. 2025. Biodegradable PCL Hybrids with 6-Aminocoumarin: A Promising Material for Antimicrobial Implants and Tissue Engineering. Fibers and Polymers, 26, 12, (2025), 5269-5281. DOI: 10.1007/s12221-025-01172-z.

Search
(IN TITLE, AUTHOR, ABSTRACT,KEYWORDS)

Advanced Search ▼

POPULAR KEYWORDS
(TOP 10 KEYWORDS)

Recent Publications
(LAST 3 YEARS)

pISSN : 1229 - 9197
eISSN : 1875 - 0052

Impact Factor(2024): 2.3