Grafting of Thermo- and pH-responsive Polymer Inside Mesoporous Silica Foam in Supercritical Carbon Dioxide for Controlled Release of 5-fluorouracil 


Vol. 18,  No. 12, pp. 2476-2480, Dec.  2017


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  Abstract

Mesocellular silica foam (MCF) grafted with thermo-responsive and pH-responsive copolymer poly(Nisopropylacrylamide-co-acrylic acid), was prepared by precipitation polymerization using supercritical carbon dioxide (scCO2) as entrainer and solvent. Vinyl-functionalized MCF was first synthesized through post-synthesis via using vinyltriethoxysilane as a coupling agent for surface modification. Entrapped monomers of N-isopropylacrylamide (NIPA) and acrylic acid (AA) were then introduced and assembled onto the vinyl-modified MCF with the aid of scCO2. The grafting copolymer performed here as an on/off switch in the release of 5-fluorouracil, as confirmed by using UV-visible absorption spectroscopy. The grafted organic content and drug loading efficiency were 65.2 wt% and 11.5 wt%, respectively. The resultant grafting composite showed potential for application in drug delivery and exhibited thermo- and pH-responsiveness to external environmental changes.

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  Cite this article

[IEEE Style]

Y. Hao, J. Zhao, G. Wang, L. Cao, J. Wang, F. Yue, "Grafting of Thermo- and pH-responsive Polymer Inside Mesoporous Silica Foam in Supercritical Carbon Dioxide for Controlled Release of 5-fluorouracil," Fibers and Polymers, vol. 18, no. 12, pp. 2476-2480, 2017. DOI: fipo-2017-18-12-2476.

[ACM Style]

Youwei Hao, Jie Zhao, Gang Wang, Liqin Cao, Jide Wang, and Fan Yue. 2017. Grafting of Thermo- and pH-responsive Polymer Inside Mesoporous Silica Foam in Supercritical Carbon Dioxide for Controlled Release of 5-fluorouracil. Fibers and Polymers, 18, 12, (2017), 2476-2480. DOI: fipo-2017-18-12-2476.

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pISSN : 1229 - 9197
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