Naringin-loaded Poly(琯-caprolactone)/Gelatin Electrospun Mat as a Potential Wound Dressing: In vitro and In vivo Evaluation 


Vol. 19,  No. 1, pp. 125-134, Jan.  2018
10.1007/s12221-018-7528-6


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  Abstract

In the present study, naringin, a flavonoid isolated from the grape and citrus fruit species, was incorporated with poly(琯-caprolactone)/gelatin composite mats in order to develop a potential wound dressing. The composite mats were prepared by electrospinning of poly(琯-caprolactone)/gelatin (1:1 (w/w)) solution incorporated with 1.50 %, 3 % and 6 % (w/w) of naringin. The electrospun mats were evaluated regarding their morphology, contact angle, water-uptake capacity, water vapor transmission rate, tensile properties, drug release, cellular response and in vivo wound healing activity. The study showed that after 2 weeks, the full-thickness excisional wounds of Wistar rats treated with the naringin-loaded dressings achieved a wound closure of higher than 94 % and the dressing containing 6 % (w/w) naringin had almost 100 % wound closure. The sterile gauze, as the control group, showed nearly 86 % of wound closure after this period of time. Our results provided evidence that supports the possible applicability of naringin-loaded wound dressing for successful wound treatment.

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  Cite this article

[IEEE Style]

M. Salehi, A. Vaez, M. Naseri-Nosar, S. Farzamfar, A. Ai, J. Ai, S. Tavakol, Me, "Naringin-loaded Poly(琯-caprolactone)/Gelatin Electrospun Mat as a Potential Wound Dressing: In vitro and In vivo Evaluation," Fibers and Polymers, vol. 19, no. 1, pp. 125-134, 2018. DOI: 10.1007/s12221-018-7528-6.

[ACM Style]

Majid Salehi, Ahmad Vaez, Mahdi Naseri-Nosar, Saeed Farzamfar, Arman Ai, Jafar Ai, Shima Tavakol, and Me. 2018. Naringin-loaded Poly(琯-caprolactone)/Gelatin Electrospun Mat as a Potential Wound Dressing: In vitro and In vivo Evaluation. Fibers and Polymers, 19, 1, (2018), 125-134. DOI: 10.1007/s12221-018-7528-6.

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