Fabrication of Biocompatible PLGA/PCL/PANI Nanofibrous Scaffolds with Electrical Excitability 


Vol. 19,  No. 9, pp. 1813-1819, Sep.  2018
10.1007/s12221-018-8265-1


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  Abstract

Application of electrospun nanofibrous scaffolds has received immense attention in tissue engineering. Fabrication of scaffolds with appropriate electrical properties plays a key role in neural tissue engineering. Since fibers orientation in the scaffolds affects the growth and proliferation of the cells, this study aimed to prepare aligned electrospun conductive nanofibers by mixing 1 %, 10 % and 18 % (w/v) doped polyaniline (PANI) with polycaprolactone (PCL)/poly lactic-coglycolic acid (PLGA) (25/75) solution through the electrospinning process. The fibers diameter, hydrophilicity and conductivity were measured. In addition, the shape and proliferation of the nerve cells seeded on fibers were evaluated by MTT cytotoxicity assay and scanning electron microscopy. The results revealed that the conductive nanofibrous scaffolds were appropriate substrates for the attachment and proliferation of nerve cells. The electrical stimulation enhanced neurite outgrowth compared to those PLGA/PCL/PANI scaffolds that were not subjected to electrical stimulation. As polyaniline ratio increases, electric stimulation through nanofibrous PLGA/PCL/PANI scaffolds results in cell proliferation enhancement. However, a raise more than 10 % in polyaniline will result in cell toxicity. It was concluded that conductive scaffolds with appropriate ratio of PANI along with electrical stimulation have potential applications in treatment of spinal cord injuries.

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  Cite this article

[IEEE Style]

H. Farkhondehnia, M. A. Tehran, F. Zamani, "Fabrication of Biocompatible PLGA/PCL/PANI Nanofibrous Scaffolds with Electrical Excitability," Fibers and Polymers, vol. 19, no. 9, pp. 1813-1819, 2018. DOI: 10.1007/s12221-018-8265-1.

[ACM Style]

Houra Farkhondehnia, Mohammad Amani Tehran, and Fatemeh Zamani. 2018. Fabrication of Biocompatible PLGA/PCL/PANI Nanofibrous Scaffolds with Electrical Excitability. Fibers and Polymers, 19, 9, (2018), 1813-1819. DOI: 10.1007/s12221-018-8265-1.

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pISSN : 1229 - 9197
eISSN : 1875 - 0052

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