Enhanced Structural Stability and Controlled Drug Release of Hydrophilic Antibiotic-Loaded Alginate/Soy Protein Isolate Core-Sheath Fibers for Tissue Engineering Applications 


Vol. 20,  No. 1, pp. 1-10, Jan.  2019
10.1007/s12221-019-8753-y


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  Abstract

Tissue engineering involves a multifunctional temporary matrix which regulates tissue regeneration through controlled drug release against infections. A nanofibrous core-sheath structured scaffold comprising a tetracycline-loaded alginate/soy protein isolate (TCH-Alg/SPI) as a core and polycaprolactone (PCL) as a sheath was developed using co-axial electrospinning. Coverage of hydrophobic PCL on TCH-Alg/SPI fibers enhanced their structural stability in aqueous solutions as unsheathed fibers rapidly decomposed and provided fast drug release. Core-sheath fibers exhibited an initial burst release at ~49 % after 6 h of immersion in phosphate-buffered saline (PBS) solution and the sustain release reached ~80 % of total loaded drug on day 14. Release characteristics of TCH-Alg/SPI fibers without PCL covering showed immediate drug release within 48 h. Core-sheath fibers investigated by disk diffusion exhibited antibacterial properties against Staphylococcus aureus and Escherichia coli. The non-toxicity of core-sheath fibers was confirmed by an indirect cytotoxicity test using human dermal fibroblasts which showed compatibility and high cell viability of up to 100 % in treated cells. TCH-Alg/SPI-PCL core-sheath fibers show promise as tissue engineering scaffolds which can act as temporary templates for tissue regeneration and exhibit antibiotic release functions against infections caused by pathogenic microorganisms.

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  Cite this article

[IEEE Style]

P. Chuysinuan, C. Pengsuk, K. Lirdprapamongkol, S. Techasakul, J. Svasti, P. Nooeaid, "Enhanced Structural Stability and Controlled Drug Release of Hydrophilic Antibiotic-Loaded Alginate/Soy Protein Isolate Core-Sheath Fibers for Tissue Engineering Applications," Fibers and Polymers, vol. 20, no. 1, pp. 1-10, 2019. DOI: 10.1007/s12221-019-8753-y.

[ACM Style]

Piyachat Chuysinuan, Chalinan Pengsuk, Kriengsak Lirdprapamongkol, Supanna Techasakul, Jisnuson Svasti, and Patcharakamon Nooeaid. 2019. Enhanced Structural Stability and Controlled Drug Release of Hydrophilic Antibiotic-Loaded Alginate/Soy Protein Isolate Core-Sheath Fibers for Tissue Engineering Applications. Fibers and Polymers, 20, 1, (2019), 1-10. DOI: 10.1007/s12221-019-8753-y.

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pISSN : 1229 - 9197
eISSN : 1875 - 0052

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