Single-nozzle Core-shell Electrospun Nanofibers of PVP/Dextran as Drug Delivery System 


Vol. 20,  No. 10, pp. 2078-2089, Oct.  2019
10.1007/s12221-019-9187-2


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  Abstract

Ciprofloxacin-loaded poly(vinylpyrrolidinone) (PVP) and dextran sulfate (Dex) (PVP/Dex) nanofibers were prepared using the emulsion electrospinning method. The physical and morphological characteristics of the prepared nanofibers were evaluated by conducting a Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) and thermogravimetric analysis (TGA). The polymer-polymer and polymer-drug interactions were determined using differential scanning calorimetry (DSC). Moreover, the formation of the core-shell structure was confirmed by transmission electron microscopy (TEM) and confocal laser microscopy. The sustained release behavior was evaluated using ultravioletvisible (UV-vis) spectroscopy, and its kinetic mechanism was investigated using Korsmeyer-Peppas, Peppas-Sahlin, and Weibull models by a non-linear regression equation. The antibacterial properties were evaluated using the disc diffusion method with respect to several wound gram-positive (Methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis, Staphylococcus aureus, and Klebsiella pneumoniae) and gram-negative bacteria (Pseudomonas aeruginosa, Salmonella typhimurium, and Proteus vulgaris). In general, the release behavior of Ciprofloxacin from PVP/Dex is controlled by diffusion in the delivery system.

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  Cite this article

[IEEE Style]

M. M. A., S. A. P. M., B. M. Thamer, A. A. N., A. M. Al-Enizi, H. El-Hamshary, M. H. El-Newehy, "Single-nozzle Core-shell Electrospun Nanofibers of PVP/Dextran as Drug Delivery System," Fibers and Polymers, vol. 20, no. 10, pp. 2078-2089, 2019. DOI: 10.1007/s12221-019-9187-2.

[ACM Style]

Meera Moydeen A., Syed Ali Padusha M., Badr M. Thamer, Anis Ahamed N., Abdullah M. Al-Enizi, Hany El-Hamshary, and Mohamed H. El-Newehy. 2019. Single-nozzle Core-shell Electrospun Nanofibers of PVP/Dextran as Drug Delivery System. Fibers and Polymers, 20, 10, (2019), 2078-2089. DOI: 10.1007/s12221-019-9187-2.

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