Alginate Nonwoven-Sponge Composite Scaffold for Rotator Cuff Tendon Repair 


Vol. 21,  No. 9, pp. 1879-1887, Sep.  2020
10.1007/s12221-020-9771-5


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  Abstract

Growth factor-mediated healing of rotator cuff tendon requires to develop a clinically applicable biomaterial playing roles of mechanical support and growth factor release in vivo. In this study, the alginate (AG) nonwoven-sponge composite scaffold (AGNWSP) was fabricated through the formation of an AG sponge layer on the AG nonwoven scaffold (AGNW) surface, and rotator cuff repair with the AG-based scaffolds containing transforming growth factor-beta 1 (TGF-棺1) was investigated with a rabbit model. AGNWSP had higher tensile strength, lower bioabsorbability, and higher sustained TGF-棺1 release capacity than AGNW, which were highly correlated with tendon regeneration. AGNW and AGNWSP were fixed to the ruptured tendon-to-bone sites, and fresh solutions of TGF-棺1 were injected into the scaffolds. When AGNWSP was applied, the repaired supraspinatus tendon had higher ultimate failure load and stress. In addition, well-organized collagen fibers and fibrocartilages were observed at the tendon-to-bone interface in this case. It is suggested that high degree of ruptured rotator cuff healing could be achieved with AGNWSP in combination with TGF-棺1.

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  Cite this article

[IEEE Style]

G. Y. Park, J. P. Yoon, J. H. Choi, "Alginate Nonwoven-Sponge Composite Scaffold for Rotator Cuff Tendon Repair," Fibers and Polymers, vol. 21, no. 9, pp. 1879-1887, 2020. DOI: 10.1007/s12221-020-9771-5.

[ACM Style]

Ga Young Park, Jong Pil Yoon, and Jin Hyun Choi. 2020. Alginate Nonwoven-Sponge Composite Scaffold for Rotator Cuff Tendon Repair. Fibers and Polymers, 21, 9, (2020), 1879-1887. DOI: 10.1007/s12221-020-9771-5.

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pISSN : 1229 - 9197
eISSN : 1875 - 0052

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