Design and In vitro Investigation of Grafted Chitosan as Chitosan Nanoparticles Containing Deflazacort Drug Coated by Calcium Starch Glycolate 


Vol. 21,  No. 12, pp. 2718-2728, Dec.  2020
10.1007/s12221-020-0042-2


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  Abstract

Novel chitosan nanoparticles (SCN) were synthesized via reaction of chitosan with different concentration of 2- chloro-N-(3-methylisoxazol-5-yl) acetamide (5 %, 10 % and 15 %) at 70-80 oC for 7 h to give the grafted polymer, which condensed with cyclohexanone Mannich base 45 oC for 7 h to afford the corresponding (SCN). These were stirred with Deflazacort drug to achieve the Deflazacort loading (SCN), which, compressed with calcium starch glycolate (CaSgly) to give the corresponding tablets. The pH 2. 1 and concentration of SCN-10 %/CaSgly (1:4) was found to be important parameters in controlling the release profiles.

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  Cite this article

[IEEE Style]

E. M. A. Bary, A. N. Harmal, b. E. Ibrahim, M. A. Gouda, "Design and In vitro Investigation of Grafted Chitosan as Chitosan Nanoparticles Containing Deflazacort Drug Coated by Calcium Starch Glycolate," Fibers and Polymers, vol. 21, no. 12, pp. 2718-2728, 2020. DOI: 10.1007/s12221-020-0042-2.

[ACM Style]

Elsayed M. Abdel Bary, Ammar N. Harmal, bMona E. Ibrahim, and Moustafa A. Gouda. 2020. Design and In vitro Investigation of Grafted Chitosan as Chitosan Nanoparticles Containing Deflazacort Drug Coated by Calcium Starch Glycolate. Fibers and Polymers, 21, 12, (2020), 2718-2728. DOI: 10.1007/s12221-020-0042-2.

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