Electrospun Nanofibers for Dual and Local Delivery of Neuroprotective Drugs 


Vol. 22,  No. 2, pp. 334-344, Feb.  2021
10.1007/s12221-021-0228-2


  Abstract

Drug delivery for neuroprotection/neuroregeneration after traumatic peripheral nerve injuries still remains a challenge. For this purpose, we formulated composite nanofiber formulation for the dual local delivery of alpha lipoic acid (ALA) and atorvastatin (ATR) to enhance regeneration process after peripheral nerve injury. The initial stage involved encapsulation of ATR into nanosprayed chitosan (CH) nanoparticles after which the CH nanoparticles were embedded into poly(lactic-co-glycolic acid) (PLGA) nanofibers containing freely dispersed ALA within the fiber structure. Morphology investigations revealed that smooth and randomly aligned nanofibers with mean diameter of 340

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  Cite this article

[IEEE Style]

M. K. Haidar, S. S. Timur, G. M. Demirbolat, E. Nemutlu, R. N. G체rsoy, K. Ulubayram, L. 횜ner, H. Ero휓lu, "Electrospun Nanofibers for Dual and Local Delivery of Neuroprotective Drugs," Fibers and Polymers, vol. 22, no. 2, pp. 334-344, 2021. DOI: 10.1007/s12221-021-0228-2.

[ACM Style]

Mohammad Karim Haidar, Selin Seda Timur, G체len Melike Demirbolat, Emirhan Nemutlu, R. Neslihan G체rsoy, Kezban Ulubayram, Levent 횜ner, and Hakan Ero휓lu. 2021. Electrospun Nanofibers for Dual and Local Delivery of Neuroprotective Drugs. Fibers and Polymers, 22, 2, (2021), 334-344. DOI: 10.1007/s12221-021-0228-2.

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pISSN : 1229 - 9197
eISSN : 1875 - 0052

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