One-Pot Preparation of Antibacterial Electrospun Polycaprolactone Membrane Embedded with Gamma Irradiation-Induced Silver Nanoparticles 


Vol. 24,  No. 1, pp. 29-44, Jan.  2023
10.1007/s12221-023-00031-z


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  Abstract

In this study, we proposed a straightforward electrospun polycaprolactone (PCL) loaded with silver nanoparticles (SNPs) membrane fabrication process, in which SNPs were directly synthesized from silver nitrate ( AgNO3) in PCL밶cetone mixture by gamma irradiation. The insolubility of AgNO3 in PCL solution was solved using an auxiliary dimethyl sulfoxide solvent. As a physical approach, gamma rays readily converted silver ions into SNPs without the addition of harmful reduction agents, which reduced the cytotoxicity of the synthesized material. By avoiding some processes such as purification, solvent removal, or redispersion of SNPs, this method was more time-saving compared to other related studies. SNPs formation was confirmed by both UV밮isible spectrum (UV밮is) and X-ray diffraction analysis. Scanning electron microscopy (SEM) revealed that the addition of SNPs significantly reduced the fiber diameter of PCL밃g membranes compared to that of raw PCL. Uniform spherical-shaped SNPs incorporated in PCL fibers were observed under transmission electron microscopy (TEM). The tensile test showed that the electrospun PCL밃g membranes exhibited good mechanical characteristics. Moisture easily penetrated the porous microstructure of PCL밃g, facilitating wound humidity regulation. Inductively coupled plasma-mass spectroscopy (ICP-MS) was employed to study the release profiles of SNPs at different time intervals. Overall, the PCL밃g 500 ppm sample exerted excellent antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus strains and low in vitro cytotoxicity.

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  Cite this article

[IEEE Style]

C. M. T. 쨌. N. T. N. 쨌. M. H. H. 쨌. V. K. D. 쨌. K. L. L. 쨌. N. D. 쨌. N. M. T. 쨌. H. T. N. 쨌. L. P. T. 쨌. T. M. D. 쨌. Q. Ngo, "One-Pot Preparation of Antibacterial Electrospun Polycaprolactone Membrane Embedded with Gamma Irradiation-Induced Silver Nanoparticles," Fibers and Polymers, vol. 24, no. 1, pp. 29-44, 2023. DOI: 10.1007/s12221-023-00031-z.

[ACM Style]

Chien Minh Tran 쨌 Ngoc Thi멦hanh Nguyen 쨌 Minh Hieu Ho 쨌 Vinh Khanh Doan 쨌 Khanh Loan Ly 쨌Nhi Ngoc멦hao Dang 쨌 Nam Minh멠huong Tran 쨌 Hoai Thi멦hu Nguyen 쨌 Long Phuoc Truong 쨌 Thai Minh Do 쨌 Quyen Ngo. 2023. One-Pot Preparation of Antibacterial Electrospun Polycaprolactone Membrane Embedded with Gamma Irradiation-Induced Silver Nanoparticles. Fibers and Polymers, 24, 1, (2023), 29-44. DOI: 10.1007/s12221-023-00031-z.

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pISSN : 1229 - 9197
eISSN : 1875 - 0052

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