Electrospun SrO-Incorporated Nanofiber Membranes for Biomedical Applications 


Vol. 24,  No. 11, pp. 3775-3786, Nov.  2023
10.1007/s12221-023-00361-y


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  Abstract

Bioactive ceramics have gained increasing interest in biomedical applications. Strontium (Sr)-based ceramics show unique bioactivity in stimulating cell proliferation and migration and promoting angiogenesis. Incorporation of bioactive ceramics into nanofibers represents a facile approach to alter the material properties of electrospun nanofiber membranes. Herein, we prepared SrO-incorporated nanofiber membranes by electrospinning and investigated the effects of SrO particles on the physicochemical properties and cytocompatibility of these membranes. Our results indicate that simple one-stream electrospinning could smoothly introduce SrO particles into poly(L-lactic acid) (PLA)/gelatin nanofibers. SrO-incorporated membranes showed significantly improved wettability but became brittle compared with PLA/gelatin nanofiber membranes. Cells differentially responded to SrO-incorporated membranes: endothelial cells showed greater cell area and coverage on SrO-incorporated membranes; in contrast, fibroblasts were inhibited on these membranes. These findings suggest that SrO-incorporated membranes might find opportunities in specific biomedical applications in which pro-angiogenesis and antiadhesion are simultaneously demanded.

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  Cite this article

[IEEE Style]

B. Sun, Z. Chen, J. Fan, Y. Ding, Y. Zhang, A. I. Abd-Elhamid, J. Wu, B. Sun, "Electrospun SrO-Incorporated Nanofiber Membranes for Biomedical Applications," Fibers and Polymers, vol. 24, no. 11, pp. 3775-3786, 2023. DOI: 10.1007/s12221-023-00361-y.

[ACM Style]

Binbin Sun, Zhe Chen, Jitao Fan, Yangfan Ding, Yunlong Zhang, Ahmed I. Abd-Elhamid, Jinglei Wu, and Binbin Sun. 2023. Electrospun SrO-Incorporated Nanofiber Membranes for Biomedical Applications. Fibers and Polymers, 24, 11, (2023), 3775-3786. DOI: 10.1007/s12221-023-00361-y.

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pISSN : 1229 - 9197
eISSN : 1875 - 0052

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