Synthesis and Characteristics of Poly(L-lactic acid-block-γ-aminobutyric acid) 


Vol. 52,  No. 1, pp. 53-58, Feb.  2015
10.12772/TSE.2015.52.053


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  Abstract

Biodegradable block copolymer of poly(L-lactic acid-block-γ-aminobutyric acid) were synthesized for the controlled release of γ-aminobutyric acid (GABA), a neurotransmitter. Poly(L-lactic acid-block-γ-aminobutyric acid) was prepared by the self-initiative polymerization of 2-pyrrolidone at the activated end group of poly(L-lactic acid), which was substituted with dehydrated 2-pyrrolidone. The molecular structure of the block copolymer was analyzed by FT-IR spectroscopy, 1H NMR spectroscopy, and XRD. The surface energies and biodegradabilities of the block copolymers were tested. The release behavior of GABA from the block copolymer matrices was investigated. The relative quantity of the blocks had an accommodative amplitude in the release of GABA.

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pISSN : 1225 - 1089
eISSN : 2288 - 6419

한국연구재단 우수등재학술지 유지 (2022년)