Effects of Phytoncide-containing Cotton Fabrics on the Development of Atopic Dermatitis 


Vol. 52,  No. 6, pp. 388-395, Dec.  2015
10.12772/TSE.2015.52.388


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  Abstract

In this study, we investigated the effects of phytoncide-containing 100% cotton fabrics on the improvement of atopic dermatitis, through preclinical trials. The finishing agents used for testing were obtained by emulsification (S2), by capsulation (S4) using phytoncide extracted with supercritical CO2, and by capsulation using solvent-extracted phytoncide (S3). The supercritically extracted phytoncide was used for in vitro testing. In the in vitro test, cytotoxicity occurred at the phytoncide concentrations of 0.1% and 0.5% in stained HaCaT cells and at 0.1% concentration in stained Raw 264.7 cells. In the in vivo test, the infiltration of inflammatory cells into skin tissue was significantly reduced in the S3 and S4 groups relative to the positive comparison group (Positive) of atopic dermatitis. Moreover, from results of the western blot and immunohistochemistry assays of tested skin tissue, we were able to confirm a reducing pattern of the markers related to keratogenesis.

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pISSN : 1225 - 1089
eISSN : 2288 - 6419

한국연구재단 우수등재학술지 유지 (2022년)