Combination Drug Release of a Nanofiber Membrane Fabricated by Coaxial Dual Electrospinning 


Vol. 55,  No. 5, pp. 330-337, Oct.  2018
10.12772/TSE.2018.55.330


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  Abstract

Coaxial dual electrospun nanofibers were designed for the sustained release of combination drugs. The nanofibers had a sheath-core structure composed of poly(ethylene oxide)/poly(D,L-lactic acid) blend in the sheath and poly(D,L-lactic acid) with drugs in the core. The properties as a carrier in a drug delivery system were analyzed using Fourier transform infrared spectrophotometry, X-ray diffractometry, scanning electron microscopy, and field emission transmission electron microscopy. The release behaviors of the combination drug of methotrexate/probucol were tested. Cumulative release amounts were proportionally increased according to the increased poly(ethylene oxide) ratio in the sheath. The initial release of probucol was approximately half that of methotrexate. In long-term release, the release rate of methotrexate decreased relatively, but that of probucol remained steady. The drug-diffusion milieu in the sheath of the coaxial nanofiber greatly affected the short- and long-term release of the drugs. The possibility of classified release control by components in combination drugs was ascertained.

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pISSN : 1225 - 1089
eISSN : 2288 - 6419

한국연구재단 우수등재학술지 유지 (2022년)