In-situ Crystalline Formation of Nano-hydroxyapatite Using Simulated Body Fluids on the Surface of Acetylated Chitosan 


Vol. 59,  No. 1, pp. 47-54, Feb.  2022
10.12772/TSE.2022.59.047


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  Abstract

Hydroxyapatite/chitosan composites are being researched as useful biomaterials for bone repair and regeneration. In order to make a biomimetic composite, the in vitro formation of apatite on the surface of the acetylated chitosan film using a simulated body fluid was tested. The formation and in-situ crystallization behavior of hydroxyapatite as a function of the degree of acetylation was investigated. The surface of the acetylated chitosan was densely covered by forming a cluster of a plate-shaped crystalline phase with a thickness of approximately 20 nm, and the crystalline cluster was identified with apatite, including hydroxyapatite. The closer the acetylation rate of chitosan was to 50%, the larger were the amount of crystalline phases formed, and the Ca/P ratio gradually increased to reach 1.67 of hydroxyapatite. As the ratio of glucosamine and acetylglucosamine in chitosan became identical, the formation of apatite was maximized and hydroxyapatite accounted for most of them.

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pISSN : 1225 - 1089
eISSN : 2288 - 6419

한국연구재단 우수등재학술지 유지 (2022년)